Platelet pressure product, is the product of the number of platelets and the average volume of platelets. The size of platelet pressure product is influenced by the number of platelets and the average volume of platelets. Increased platelet pressure product, common causes: i. Increased average platelet volume, seen in primary thrombocytopenic purpura, myelodysplastic syndrome, acute leukemia in remission, late pregnancy, megaloblastic anemia, thrombophilia, etc. It may be caused by elevated platelet count, which can be seen in myelodysplastic syndrome, chronic granulocytic leukemia, acute blood loss, acute hemolysis, post-splenectomy, etc. Second, a decrease in platelet pressure volume, which can be seen in a decrease in the average volume of platelets, such as after chemotherapy for acute leukemia, aplastic anemia, and hypersplenism. It may be caused by a decrease in the number of platelets, seen in aplastic anemia, acute leukemia, radiation therapy and chemotherapy, thrombocytopenic purpura, hypersplenism, etc.