Estradiol Dydrogesterone Tablets are generally not obviously harmful to the body, but there are certain side effects that can lead to adverse effects on menstruation, gastrointestinal tract, breasts as well as skin. 1. Menstruation: It may cause mild vaginal bleeding, change of menstrual period and menstrual flow, or even amenorrhea. 2. Gastrointestinal tract: It may cause gastrointestinal discomfort, such as nausea, vomiting, diarrhea and abdominal pain. 3. Breasts: long-term use of the drug may cause breast hyperplasia, inducing mild breast pain, and may even induce benign endometrial hyperplasia. 4. Skin: it is easy to induce skin allergic reaction, cause skin itching, and even cause rash as well as hives and other skin diseases. Estradiol Dydrogesterone Tablets are contraindicated for patients with a history of breast cancer as well as acute liver disease. In addition, the application of estradiol dydrogesterone tablets has certain risks, patients need to get the guidance of specialized doctors.