The pain in the middle of the thigh may be caused by muscle strain, lumbar disc herniation, muscle strain, dermatoneuritis, bone tumor and other reasons. 1. Muscle strain: if strenuous exercise or too much activity can cause thigh muscle strain walking pain, can be improved after rest. 2. Lumbar disc herniation: the herniated nucleus pulposus compresses the nerves and can cause radiating pain in the middle of the thigh, and in some cases, there will be numbness. 3. Muscle strain: muscle injury with localized swelling, pressure and pain, and activity limitation. 4. Dermal neuritis: the dermal nerve compression causes pain in the innervated area and local sensory impairment. 5. Bone tumor: mainly manifested as local pain, mass, imaging examination can help diagnosis. If the pain in the middle of the thigh is not alleviated by rest, you should go to the hospital in time, and standardize the treatment under the guidance of the doctor.