Granuloma may be caused by not paying attention to eye hygiene, eye fatigue and eye diseases, sebaceous gland secretion and so on. 1. Not paying attention to eye hygiene: often rubbing the eyes with dirty hands, unclean water into the eyes, so that staphylococcus bacteria repeatedly infect the eyes, which leads to the phenomenon of granuloma. 2. Eye fatigue and eye diseases: excessive eye use, refractive error and long-term eye fatigue patients are prone to granuloma, people with trachoma, chronic conjunctivitis are also more likely to suffer from granuloma. 3. Excessive sebaceous gland secretion: People who often consume oily food in their life, the secretion of sebaceous glands will be more exuberant than the general public, and this situation will easily make the sebaceous gland secretion outlet blocked, which will ultimately lead to the occurrence of granuloma. If there is a recurrence of wheals, you should go to the hospital in time and be treated under the guidance of the doctor.