There is usually no conflict between vaccination with the New Crown vaccine and taking entecavir. If you take entecavir every day, if you are stable, your liver biochemistry has been normal, you have no other diseases, and you are not allergic to the vaccine, you can receive the New Crown vaccine. If a patient is unsure of their condition and is unsure if they can receive the New Crown vaccine, it is recommended that they consult their primary care physician. Entecavir is mainly used to treat chronic adult hepatitis B with active lesions. Patients with chronic hepatitis B who are in the active phase of the disease, have abnormal liver biochemistry such as significantly elevated transaminases and the presence of ascites, etc., cannot receive the New Crown vaccine temporarily and need to wait until their condition is stabilized and their liver biochemistry returns to normal before receiving the vaccine. Entecavir can also be combined with the application of immunosuppressants to prevent the hepatitis B virus from being activated, and if this is the case, the New Crown vaccination is not recommended. Because immunity decreases when immunosuppressants are applied and antibodies are not easily produced after vaccination, the injection is not recommended. Patients who take entecavir every day and who have been vaccinated under the advice of a doctor, like others, need to take rest, avoid alcohol and spicy and irritating food and seafood. If minor adverse reactions occur, they can usually recover on their own without special treatment. If the adverse reaction is serious or lasts for a long time, you need to go to the hospital in time. For the new crown vaccine currently listed in China, those who cannot be vaccinated mainly include patients with acute diseases, patients with acute exacerbation of chronic diseases, patients with autoimmune diseases, patients with fever and those who are allergic to vaccine components.