Treatment of plaque psoriasis

  1. Etiology Chinese medicine has an early understanding of this disease, and the treatment of this disease has been based on blood heat and blood deficiency for many generations. In recent years, with the improvement of the theory of activating blood circulation and resolving blood stasis, Chinese medicine has further developed its understanding of this disease. A large number of studies have shown that blood heat is the fundamental pathogenesis of psoriasis, and blood stasis is the basic pathological change of plaque psoriasis, which occurs in two ways: one is that a variety of factors such as external sensation and internal injury cause qi to stagnate, and qi is the handsome of blood, and qi stagnation obstructs blood flow, resulting in qi stagnation and blood stasis; the other is that the disease lasts for a long time, blood heat remains for a long time, blood flow is not smooth, and heat knots blood stasis. Most of the plaque psoriasis is due to recurrent attacks and long duration of the disease, the flow of qi and blood is not smooth, resulting in stagnation of the meridians, stasis of qi and blood, loss of nourishment of the skin, resulting in skin infiltration and hypertrophy, purple or dull red color, dark purple tongue with petechiae, astringent or slow pulse, the treatment should cool the blood and activate the blood, detoxify and search the wind.  2. Treatment In long-term clinical practice, the treatment of plaque psoriasis with the self-designed “Angelica detoxification soup” has good efficacy, short course of treatment, low toxic side effects and not easy to relapse, which has produced good social benefits among many patients. Angelicae antidote Tang is mainly composed of Angelicae, Salviae, Ocimum sanctum, Paeonia lactiflora, Poria, Cao He Che, Yu Jin, Dendrobium, Cyperus alba, Atractylodes, Poria and Licorice. On the basis of this formula, we can also add and subtract with the evidence. If the scales do not recede for a long time, we can add Trigonella and Curcuma longa; if the scales are thick, we can add Angelica sinensis and Cortex rotunda; if the skin lesions are dry and the yin is injured, we can add Yu Zhu and Bei Sha Shen. The main indications of this formula are plaque-like damage in patients with psoriasis; dark red lesions with a medium amount of scales; itchy or non-itchy; dark red tongue and astringent or slow pulse.  3. Case example Wang, male, 45 years old, was first diagnosed on September 12, 2004. He complained of recurrent scaly dark red patches with itching all over the body for 6 years, aggravated for 2 weeks. The patient had a few patches on the top of the head 6 years ago, covered with silvery white scales, after which the rash gradually increased, spreading to the extremities and trunk, with obvious itching, heavy in winter and light in summer, and recurrent episodes, using a variety of Chinese and Western drugs with no obvious effect. Physical examination: large hypertrophic infiltrative plaques scattered in front of the shins, waist and back, and scalp, varying in size and irregular shape, dark red, covered with a few scales, dark purple tongue, white greasy coating, thin and slow pulse. Traditional Chinese medicine diagnosis: Bai Qi (blood stasis and wind dryness evidence); Western medicine diagnosis: psoriasis. The treatment is to cool the blood and invigorate the blood, detoxify the toxin and search the wind. Prescription: Salvia miltiorrhiza 30g, Ocimum sanctum 10g, Paeonia lactiflora 15g, Fu Ling 30g, Cao He Che 15g, Yu Jin 10g, Dendrobium 15g, Atractylodes macrocephala 30g, Atractylodes macrocephala 12g, Poria 10g, Glycyrrhiza glabra 6g. Decocted 3 times with water and divided into 3 doses. Dampness cream and Wu Bei Zi cream (the drug is a homemade traditional Chinese medicine for external use in our dermatology department, the main function is to relieve itching and moisten the skin, this case is used as an adjunctive treatment) were mixed and used externally. After taking the above 14 doses, the itchy rash was reduced and the scaling was reduced. After taking another 14 doses, the skin lesions became darker, part of the center has fading phenomenon, the above add chicken blood vine 10g, San Ling 10g, topical medicine with the previous. After taking the above 28 doses, in addition to a few residual lesions in front of the shin, the other lesions have basically disappeared, only pigmented spots. Followed by the formula plus reduction of conditioning for 1 month, the basic cure. This case is a patient with winter-type plaque psoriasis, who started to take medicine in September, and the lesions showed clinical cure after winter.  4. Discussion Plaque psoriasis is considered a stubborn and difficult to treat skin disease in dermatology. Angelica antitoxin soup is an empirical formula for the treatment of plaque psoriasis formulated on the basis of the identification and treatment of a large number of clinical patients, and is composed of Dan Shen, Ocimum sanctum, Tu Fu Ling, Cao He Che and Bai Hua Tongue and Snake Herb. It is believed that the basic pathogenesis of plaque psoriasis is blood stasis and wind dryness, and the treatment is to cool the blood and invigorate the blood, detoxify the toxin and search the wind. The formula is based on Salvia miltiorrhiza and Ocimum sanctum as the main medicines, and the “Justice of the Materia Medica” says: “Salvia miltiorrhiza specializes in blood, its function is to invigorate the blood and move the blood, the internal ones reach the internal organs and resolve stagnation …… external ones benefit the joints and open the meridians.” It has the function of activating blood circulation and resolving blood stasis, “Kaibao Ben Cao”: “Ouzo snake main wind itchy rash, skin is not benevolent, stubborn paralysis of all winds, all snake medicine are running, have the function of dispelling wind and pass through the channels, the disease long evil deep pronounced. Modern pharmacological research, Dan Shen and snake have obvious microcirculation and inhibit the role of inflammatory response; Fu Ling, Cao He Che, white flower snake tongue grass, red peony to clear heat and detoxify, remove dampness and relieve itching for the minister; White peony, Dendrobium nourish blood and astringent Yin, Yu Jin live blood and move Qi to help the main drug live blood and detoxify the wind for the function of adjuvant; Poria to strengthen the spleen and benefit Qi, licorice and all drugs, two drugs to protect the stomach gas, to prevent the drug for a long time to hurt the stomach, for the The medicine of the formula. In a word, the cubes of Angelica detoxification soup are well documented, the combination is reasonable, and the curative effect is exact.  With regard to the treatment of psoriasis, it is emphasized that the following keys must be seized: 1. seize the early stage, pay attention to the foci of disease and the causes of disease onset, especially the early onset of upper sensation and tonsillitis, and reasonably clear heat and detoxify and cool the blood, so that the disease will be eliminated in the process.  2, pay attention to nourishing Yin and nourishing blood, blood heat type in the administration of cooling blood, clearing heat and detoxifying drugs at the same time, should be appropriate application of nourishing Yin drugs, such as raw earth, dendrobium, yu zhu, etc., should prevent blood heat injury Yin and love evil, for the late complete recovery of the skin lesions to lay a good foundation.  3. Do not use blood cooling and heat-clearing medicine without restriction. Long-term use of a large amount of bitter cold heat-clearing medicine will hurt the spleen and stomach on the one hand, and may cause blood stasis on the other hand, resulting in stubborn plaques that are difficult to retreat.  4, for the quiescent plaque psoriasis can be added to break the qi and activate the blood medicine, so that the lesions turn into subacute state, which is conducive to the improvement of the disease.  5.Psoriasis should be treated regularly in the early and progressive stages, and those who are already in a chronic state should be regulated from the mind and body, and treated reasonably with drugs, which should be slow rather than urgent, and avoid abusing hormones and other immunomodulators.  In order to prevent and reduce the recurrence of psoriasis, preventive internal Chinese medicine should be taken one month before the onset of psoriasis, and Chinese medicine should be continued to consolidate the treatment after the skin lesions have basically subsided. Although Western medicine has reached the level of genetic and molecular biology in the treatment of psoriasis, the efficacy of Chinese medicine is still certain. In the future, how to develop Chinese medicine and its extracts for the treatment of psoriasis in greater depth, the corresponding pharmacology, pharmacokinetics and experimental research on the regulatory mechanism of Chinese medicine should be further developed, which will help to better improve clinical efficacy and provide theoretical basis. This will help to improve clinical efficacy and provide theoretical basis.