The swelling of the hands at night needs to be distinguished from local or systemic conditions.1. Local conditions are commonly caused by inflammation, trauma or thrombosis of the upper extremities or neuropathy, which need to be examined accordingly to confirm the diagnosis. If both hands are swollen, it may be caused by allergies; 2, excluding the local lesions, it is the systemic lesions, such as cardiac disease, renal disease, rheumatism, endocrine system diseases, etc. can appear hand swelling sensation. Severe patients can be accompanied by lower limb edema and pleural effusion, abdominal effusion, need to do the appropriate examination to confirm, for example, cardiac disease, there can be a history of cardiac disease, arrhythmia and other symptoms of heart failure, and renal disease can increase the foam in the urine, rheumatic disease is the most common is rheumatoid arthritis and systemic lupus erythematosus, can be accompanied by alopecia, rash, and painless ulceration of the oral cavity They can be accompanied by hair loss, skin rashes and painless oral ulcers. Endocrine diseases such as diabetes mellitus and thyroid disorders also have their own distinctive features that can help in differential diagnosis.