Progesterone must be used before transplantation in artificial cycles. Artificial cycle is to use the sequential action of estrogen and progesterone to simulate the normal menstrual cycle, so that the endometrium produces cyclic changes, and when the endometrium reaches about 0.7~0.8cm, the endometrium is transformed by using progesterone, so that the endometrium is suitable for the embryo to implant, and then the time of transplantation is chosen. Progesterone is already used in the artificial cycle itself, and since progesterone is needed to maintain normal fetal implantation and development after the transplantation, it is necessary to use progesterone before transplantation in the artificial cycle, and the use of progesterone cannot be stopped after transplantation. After successful implantation, HCG, estrogen and progesterone values should be closely monitored, and the dose of progesterone should be increased if necessary. The use of progesterone needs to be formulated by the doctor according to the specific circumstances of the individualized diagnosis and treatment plan, to achieve the purpose of normal pregnancy and childbearing, do not blindly use their own medication. To avoid adverse effects.