When esophageal cancer patients have pain symptoms in advanced stage, they can achieve effective relief of pain through psychological counseling, medication, surgery or other treatments. 1. Psychological counseling: pain caused by advanced esophageal cancer is very likely to cause psychological problems and even lead to suicide, so it is necessary to intervene in the treatment through psychological counseling, which can not only improve the psychological problems, but also enhance the pain-relieving effect exerted by other treatment modes. 2. Medication: Three-step medication for pain relief is a common treatment to cope with pain caused by cancer. For mild pain, non-opioid analgesics such as aspirin and ibuprofen can be used; for moderate to severe pain, opioid analgesics such as codeine, morphine and fentanyl can be used. 3. Surgery: Surgery can also be used to cut off the pain-conducting nerves to reduce pain, but it should be used with caution. 4. Others: In addition, patients with esophageal cancer can also treat esophageal cancer itself through radiotherapy, radiofrequency ablation therapy and other treatments to relieve pain. There is basically no cure for esophageal cancer that has developed to advanced stage, but adopting reasonable and effective pain relief methods to reduce the pain caused by the disease can help patients improve the quality of survival. When esophageal cancer patients are troubled by pain, it is recommended to follow the doctor’s prescription and use appropriate ways to dispose of it.