Malignant tumor is more malignant, some treatment effect is poor, several symptoms will appear in the late stage, the appearance of these symptoms suggest that the patient’s condition is very critical, specifically including the following symptoms: 1, in the late stage, the pain will be more intense, and the pain continues not to relieve, pain in many parts of the body, etc.; 2, severe wasting, the patient’s weight loss is very obvious, than the original weight may have dropped 20% or The fever does not go away, whether it is high fever or low fever does not go away, this kind of continuous fever may burn 1-2 weeks; 4, anorexia, to the critical late stage, to many food or its previous love of food also do not love to eat, or even do not eat; 5, breathing difficulties, breathing has reached the inability to breathe on their own, the need for oxygen, or Breathing difficulty is very heavy, need to sit and breathe; 6, severe cough, to the critical late stage, this cough will appear continuous cough, and even affect breathing; 7, the symptoms of general weakness, patients sitting in bed are feeling weak, or talking with people for 5 minutes are feeling weak weakness; 8, serious insomnia, unable to sleep, may be sleepless all night; 9, urinary incontinence, in the late stage there may Patients may have urinary incontinence in the advanced stage, indicating that the patient’s autonomic control is declining; 10, swallowing difficulties, patients in the advanced stage may not be able to eat, or will appear to choke when swallowing saliva; 11, bleeding, in the advanced stage will appear coughing up blood, fecal bleeding, urine bleeding or subcutaneous bleeding, nasal bleeding, etc.; 12, bedsores, some patients will be bedridden for a long time, individual location will have bedsores, such bedsores These bedsores can be very serious and are difficult to be relieved even after treatment and are getting larger in scope.