Survival rate of highly differentiated gastric cancer has no exact value, which is related to the stage of the disease, treatment means, their own situation and other factors, and cannot be generalized. With standardized treatment, the 5-year survival rate of gastric hyperfractionated cancer is about 90% in early stage and less than 10% in late stage. There are many types of gastric cancer, and highly differentiated cancer is one of them, because it is well differentiated and less malignant, and the probability of metastasis and recurrence after surgery is small. Early stage highly differentiated gastric cancer, i.e., still below the mucosa or submucosa, with or without lymph node metastasis and without distant metastasis, has a better prognosis with a 5-year survival rate of about 90% after active treatment. If there is distant organ metastasis, that is, advanced stage, the patient’s general condition is poorer, and the 5-year survival rate is less than 10%. The survival rate of gastric hyperdifferentiated cancer cannot be generalized. Once diagnosed, patients are advised to consult the doctor in time and take active treatment to avoid delaying the condition.