I. Definition Diabetic neuropathy is one of the common chronic complications of diabetes, which can involve sensory, motor and autonomic nerves. The literature reports that the incidence of DN varies from 60% to 90%, among which diabetic peripheral neuropathy (DPN) is the most common, manifesting as abnormal sensation and pain in the extremities, usually with more symptoms in the lower extremities than in the upper extremities. Diabetic peripheral neuropathy can cause a decrease in the body’s sensory function to pain and temperature, the patient’s protective sensory loss, prone to ulceration, infection, diabetic foot, and eventually may lead to amputation. In addition, poor response to hypoglycemia, poor response to angina pectoris, and high mortality rate in diabetic peripheral neuropathy were found. Therefore, early diagnosis and early treatment are needed. The latest statistics show that about 40% of patients are asymptomatic, so it is very important to use tools for early screening of diabetic peripheral neuropathy. Screening tools The screening items recommended in the 2010 Diabetes Guidelines are: pinprick sensation, temperature sensation, vibration sensation, pressure sensation, and ankle reflex. V. Diagnostic criteria Abnormalities in any of the symptoms, screening items, and nerve conduction velocity are diagnostic.