The diabetic foot is one of the most serious complications of diabetes mellitus. Its etiology involves various factors such as nerve endings damage due to hyperglycemia, abnormalities in microvascular blood circulation, recurrent infections, and difficult wound healing. WHO definition of diabetic foot: foot infections, ulcers and/or deep tissue destruction associated with local nerve abnormalities and peripheral vascular lesions in the distal lower extremities. definition of IWGDF: trauma involving the entire skin below the ankle in diabetic patients, independent of the course of such trauma. The etiology of diabetic foot includes: ① neuropathy: sensory, motor and autonomic neuropathy; ② vascular pathology; ③ circulatory disorders; ④ immune disorders; ⑤ reduction of insulin growth factor-1 (IGF-1) in the skin that promotes skin growth. The main of these are neurological and vascular lesions. Signs and symptoms of diabetic foot vary depending on the course of the disease and severity of the lesion. In mild cases, there is only minimal foot pain and skin surface ulcers; in moderate cases, deep penetrating ulcers combined with soft tissue inflammation can occur; in severe cases, the ulcers are combined with soft tissue abscesses, bone histopathy, limited gangrene of the toes, heel or forefoot dorsum, and even whole foot gangrene and eventual amputation can occur. Therefore, the meaning of diabetic foot can be summarized as: the destruction of foot tissues caused by diabetes, unrelated to other traumatic factors, and it is especially important to note that diabetic foot is the process of progressive damage to the foot due to nerve and blood vessel damage caused by high sugar, and it is not necessarily called diabetic foot after there is a wound or gangrene.