If you wake up with an uncomfortable heart, first consider whether there is myocardial ischemia, hypoxia, and heart discomfort, which often manifests clinically as chest tightness, chest pain, panic and shortness of breath, especially in the elderly, patients with previous hypertension, coronary artery disease, diabetes, obesity or hyperlipidemia, and do not ignore the performance of heart discomfort after waking up. It is recommended to seek medical attention for further examination of ECG or 24-hour ambulatory ECG, ambulatory blood pressure, cardiac ultrasound and, if necessary, cardiac enzymes or coronary CTA. morning sympathetic activation often causes elevated blood pressure, increased heart rate and increased myocardial oxygen consumption, resulting in myocardial ischemia. it is very important to make a clear diagnosis and early treatment in time.