Piriformis syndrome is more painful after drinking medicine can be taken to avoid sitting and standing and other general treatment, physical therapy, drug therapy and surgical treatment and other methods of integrated treatment. 1. General treatment: avoid sitting or standing, avoid lying down too much, and keep warm. 2. Physiotherapy: localized hot packs, microwave, infrared heat therapy and other physiotherapy to relieve tense muscles and help reduce the patient’s symptoms. 3. Drug therapy: when pain can be taken with diclofenac sodium, celecoxib and other anti-inflammatory pain relieving drugs or ethopiridone and other muscle relaxing drugs, when the effect is poor or aggravated, hormones and local anesthetic drugs can be used to carry out local closed treatment. 4. Surgical treatment: for the above conservative treatment of poor patients, surgical treatment can be taken. Piriformis syndrome more pain after drinking medicine is recommended to go to the hospital in a timely manner, early formal treatment, in order to reduce the adverse effects of the disease.