Tingling pain all over the body two years after ovarian cancer surgery needs to be combined with the cause of the disease, and the right treatment should be chosen according to the cause of the disease. Tingling pain in the whole body two years after ovarian cancer surgery may be related to abdominal metastasis, causing retroperitoneal lymph node metastasis, resulting in pain caused by invasion of nerve plexus, or due to bone metastasis, pain caused by destruction of bone mass and periosteum. It is recommended to give non-opioid drugs as prescribed by the doctor, and weak opioid drugs such as codeine if the effect is poor; for severe pain, strong opioid drugs such as morphine are given. In addition, radiotherapy and targeted drug therapy are needed to relieve the symptoms fundamentally. It is recommended that when symptoms occur, early medical attention should be sought to clarify the diagnosis, and treatment should be carried out according to the doctor’s instructions.