It is not possible to simply say that a certain antihypertensive drug is better for lowering blood pressure, and the most appropriate drug should be selected according to the patient’s specific situation. At present, there are five major categories of first-line antihypertensive drugs commonly used in clinical practice, which are calcium antagonists, angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor antagonists (ARBs), beta-blockers, diuretics and so on. Calcium antagonists, commonly used drugs include amlodipine, nifedipine controlled release tablets and so on. Drugs in the ACEI class, commonly used are captopril, enalapril, benadryl, etc. Drugs in the ARB class, including valsartan, temesartan, and closartan potassium. Beta-blockers, such as metoprolol, bisoprolol, etc. Diuretics mainly include hydrochlorothiazide, furosemide, etc. The above five types of antihypertensive drugs should be directed by a doctor according to the specific condition of the patient. For example, hydrochlorothiazide’s effect of lowering systolic blood pressure is significantly better than that of diastolic blood pressure. β-blockers are suitable for patients with hypertension combined with angina pectoris, myocardial infarction, heart failure, cardiac arrhythmia, glaucoma and pregnancy. Long-acting calcium antagonists have good prevention of stroke, vascular dementia and anti-atherosclerosis effects, and do not affect glucolipid and electrolyte metabolism. In summary, should follow the doctor’s advice to choose the right antihypertensive drugs, can get good antihypertensive effect, the comprehensive benefit is higher, not blindly compared to others.