Valsartan hydrochlorothiazide tablets and Irbesartan two antihypertensive drugs have their own characteristics, and there is no one better. 1. Valsartan hydrochlorothiazide tablets: can antagonize the angiotensin receptor and act on the distal tubule of the kidneys, have vasodilatation, reduce blood pressure and increase the role of diuresis, suitable for the treatment of mild to moderate essential hypertension that can not be controlled by a single drug, etc., may be dizziness, coughing, nausea and other adverse reactions, women in pregnancy, severe liver damage, hypokalemia is contraindicated. 2. Irbesartan: through the inhibition of angiotensin, reduce the release of aldosterone, produce antihypertensive effect, patients with hypertension has a very good antihypertensive effect, clinically commonly used in the treatment of essential hypertension, there may be headache, dyspepsia, diarrhea, and other adverse reactions, Irbesartan allergy patients are prohibited, lactating pregnant women are prohibited, severe liver and kidney damage patients are prohibited. The medication should be taken under the guidance of a doctor and selected according to their own situation, and should not be taken blindly on their own to avoid causing other damage.