Stubborn acne marks, i.e. hyperpigmentation can be improved in the following ways to improve the appearance, including topical medication, oral medication and physical therapy. 1. Topical medication: For stubborn acne marks, you can first use topical decolorant treatment, such as hydroquinone cream, azelaic acid cream, etc., which can lighten the melanin; you can also use topical exfoliators, such as retinoic acid ointment, adapalene gel, etc., which can exfoliate the keratin and lighten the hyperpigmentation. 2. Oral medication: Oral antioxidant drugs, such as vitamin C, vitamin E, etc., to reduce the production of melanin. 3. Physical therapy: when the above two methods of treatment are ineffective, you can take intense pulsed light, fractional laser, pulsed dye laser and other physical methods, which can effectively lighten the local acne marks. It is recommended that patients go to the dermatology department of regular hospitals and follow the doctor’s instructions for reasonable treatment. Strictly under the guidance of specialized doctors to use drugs, not blindly self-medication. Normally, we should do a good job of sun protection, so as not to induce melanin deposition.