Cold and fever with generalized weakness is usually caused by viral infection. It can be relieved by resting, drinking plenty of water, physical cooling, etc. If the symptoms are serious, it can be relieved by taking medicines such as cold and flu granules, anti-viral oral solution and ibuprofen. Colds are generally caused by viral infections such as rhinovirus and adenovirus, which may result in symptoms such as runny nose, sneezing, fever, generalized weakness, etc. It is a self-limiting disease, and can be relieved by resting and avoiding exertion; avoiding oily and spicy food in diet; and eating more light, protein-rich food such as milk and eggs to strengthen nutritional support. If the symptoms are more serious, you can take cold and flu granules, antiviral oral solution, etc. to relieve. For fever, physical cooling such as wiping with warm water can be used first. If the effect is not good, you can use antipyretic drugs such as acetaminophen and ibuprofen suspension to treat the symptoms. When the patient shows a rapid onset of symptoms, chills, high fever, generalized weakness, etc., need to consider the influenza virus infection, can use oseltamivir and other drugs antiviral treatment. If the symptoms are severe and continue to be unrelieved, it is necessary to actively consult a doctor and use medication under the guidance of a physician.