Common systemic reactions to the HPV vaccine include fatigue, headache, muscle aches, fever, gastrointestinal reactions such as nausea and vomiting, joint pain, itching, rash, hives, etc. Rare systemic reactions include occasional upper respiratory tract infections, dizziness, local sensory abnormalities, lymphadenopathy, etc. Some local reactions may also occur after vaccination. Very common local reactions include pain, redness and swelling at the injection site, and less common are hard nodules at the injection site. Compared with the quadrivalent vaccine, the nine-valent vaccine has a higher incidence of local adverse reactions, but the incidence of systemic side effects is basically the same. There have not been any vaccine-related deaths in clinical trials.