High fever of bile duct cancer in the afternoon every day is considered to be caused by tumor fever, bile duct infection and infection in other parts of the body. 1. Tumor fever: when bile duct cancer reaches middle or late stage, due to abnormal blood circulation of cancerous lesions, ischemic necrosis occurs in cells, and the necrotic cells act as a source of heat, which has a stimulating effect on thermoregulation, and it can lead to recurrent symptoms of high fever. 2. Bile duct infection: cancerous tissues in the bile duct can easily block the bile duct, which can lead to the obstruction of bile discharge and easily cause bacterial infection. After bacterial infection occurs in the bile duct, it will easily cause symptoms such as recurrent high fever, abdominal pain and jaundice. 3. Infection in other parts: cholangiocarcinoma can easily cause systemic immunity and function of organs, which will easily lead to infection, such as lung infection and urinary tract infection. The body will have the symptom of repeated high fever after infection. It is recommended to go to the hospital in time to check the specific cause and treat it in order to avoid delaying the condition of cholangiocarcinoma.