Both closed-angle and open-angle glaucoma have a genetic link. Closed-angle glaucoma is a polygenic disease, with 32% of the patient’s siblings having narrow anterior chamber angles and 6% of them developing glaucoma. The prevalence is six times higher in those with a family history than in those without a family history. Open-angle glaucoma is also a polygenic disease, with genetic predisposition accounting for 13% to 47% of the overall incidence and 3.5% to 16% of the incidence in relatives with glaucoma. A recent study by researchers at the University of Arizona found that the root cause of glaucoma is related to mutant proteins and mutant genes. The protein, known as “mioicillin,” was found to be present in the part of the eye associated with fluid outflow and is essential for maintaining pressure in the eye. Studies have shown that the “mioicillin” protein appears to control how tightly the cells of the eye bind, which acts like a door to control the penetration of fluid in the eye, and that the cells of the eye are too tightly bound in glaucoma patients. In addition, patients with hereditary glaucoma have a defect in the morphology of the miosin protein. Therefore, if you have parents or grandparents with glaucoma, you should be vigilant and get checked early.