Whether glaucoma can be passed on to the next generation is a question of interest and significance to many people. Existing studies have proven that the development of glaucoma is characterized by a polygenic genetic disease. Since there are multiple types of glaucoma, the mode of inheritance varies. At least eight chromosomal loci are known to be associated with the development of open-angle glaucoma and normal-intensity glaucoma; and the MYOC/TIGR and OPTN genes have been identified as the causative genes for glaucoma. The prevalence of primary open-angle glaucoma is high in the African American population, and thus having a family history of glaucoma is one of the most significant risk factors for developing glaucoma. Approximately 10% of patients with primary congenital glaucoma have significant autosomal recessive inheritance characteristics. In such cases, the parents are usually only carriers of heterozygotes and do not develop the disease. Simply based on Mendelian principles of inheritance, if heterozygous carrier parents have four children, statistically these four children will appear as follows: one child carries the heterozygote for primary congenital glaucoma and develops the disease: two children are simply heterozygous carriers; the other child is normal. But the reality is much more complex than these results. Some investigators have also found that if the affected boy is in the family, the prevalence of other siblings is 3%, and if the affected girl is in the family, the prevalence of other siblings is almost zero. Therefore, people with a family history of glaucoma should go to the hospital for regular checkups. Once they find that they have abnormalities such as eye swelling, headache, and rainbow vision, they must go to the hospital for checkups and take the initiative to tell the doctor that they have a family history of glaucoma in order to cooperate with the doctor for timely diagnosis and treatment.