There is no epilepsy drug with minimal side effects, only relatively minor, the new generation of antiepileptic drugs currently on the market have relatively minor toxic side effects compared to the previous generation of antiepileptic drugs. There are many drugs currently available for the treatment of epilepsy, which can basically be categorized into first-, second- and third-generation antiepileptic drugs. Third-generation antiepileptic drugs, such as Pirempanel, Pregabalin, Coluracetam, and Eslicarbazepine, are newer antiepileptic drugs on the market, which can stabilize the blood concentration of epileptic patients, and have better efficacy and fewer side effects relative to second-generation antiepileptic drugs. Clinically used antiepileptic drugs, there are also second-generation antiepileptic drugs such as gabapentin, topiramate, levetiracetam, etc., and first-generation antiepileptic drugs such as carbamazepine, phenobarbital, phenytoin sodium, and clonazepam. First-generation antiepileptic drugs have relatively large side effects compared to second- and third-generation, with suppression of bone marrow, impairment of liver function and cognitive effects on the side. Epilepsy patients in the choice of drugs is not based on the size of the side effects to decide, the side effects of small is not necessarily suitable for their own condition, should be by the doctor according to the condition and the actual situation to comprehensively consider the choice of appropriate drugs.