Hypothermia after 13-valent pneumonia vaccination is often due to adverse reactions to the vaccine and is a relatively common clinical phenomenon. The treatment of hypothermia does not require the use of antipyretic drugs. It is sufficient to control the body temperature to the normal range by drinking more water, repeatedly rubbing the body with warm water, and using ice to cool the body if necessary, and the symptoms of hypothermia will not last long and will soon return to normal. If the baby has symptoms of upper respiratory tract infection after vaccination, accompanied by cough, sore throat, sneezing and other manifestations, it is necessary to use medication. It is recommended to clarify whether there is bacterial infection through routine blood tests, and if necessary, choose anti-inflammatory and anti-viral drugs to control the infection.