Pain in the middle of both shoulders can be caused by aseptic inflammation, trauma, muscle fatigue, muscle spasm and other factors. 1. Aseptic inflammation: Rheumatic joint of shoulder, rheumatoid arthritis and gouty arthritis, etc. In addition to pain and limitation of activity in the affected area, radiating pain can also occur in the middle of both shoulders. 2. Trauma: Shoulder pulling, sprain and other injuries, or direct external injury to the middle of both shoulders, can lead to local pain, swelling and activity limitation and other discomforts. 3. Muscle fatigue: Long-term high-intensity exercise or labor of the upper limbs can lead to bilateral soft tissue pulling in the middle of the shoulder, causing fatigue of the local muscles and tendons, which can cause pain and discomfort, and can be aggravated when the activity is strenuous. 4. Muscle spasm: when cervical spondylosis, frozen shoulder and other diseases, the local posture is fixed for a long time and the activity is limited, or the nerve is compressed, which can lead to spasm of the middle shoulder muscles on both sides, and the pain and discomfort symptoms can appear. If you have pain in the middle of both shoulders, you should consult a doctor in time and take appropriate treatments under the guidance of a specialist to help relieve the pain and other discomforts as soon as possible.