There are many drugs for the treatment of insomnia, but we should pay attention to the indications and adverse reactions of the drugs and follow the principle of individualized and on-demand medication. Commonly used drugs for insomnia are as follows: 1, benzodiazepines: also commonly known as Valium, is the most commonly used drugs for clinical treatment of insomnia. According to its duration of action is divided into short-acting, medium-acting and long-acting preparations, commonly used representative drugs are midazolam, lorazepam and diazepam. 2, non-benzodiazepines: these drugs do not affect the normal sleep physiology of healthy people, is also the preferred clinical hypnotic drugs, which are commonly used on behalf of zolpidem, dezopiclone, zopiclone, etc. 3, melatonin receptor agonists: can be used for circadian rhythm disorders, as well as the difficulty of falling asleep as the main sleep, the representative drugs are ramelteon. Antidepressants with sedative effect: some insomnia is caused by depression or anxiety, such drugs can improve depressive symptoms, while having a sedative effect, the main representatives of the drug are mirtazapine, trazodone. It should be noted that the treatment of insomnia, first of all, to exclude the cause, to develop good sleep habits, behavioral therapy is the cure, drug treatment must follow medical advice.