Low platelet width of distribution is not necessarily anemia. A low platelet distribution width often reflects a decrease in platelets in the body and is commonly seen in aplastic anemia and other conditions with reduced hematopoietic function. If a patient only has a low platelet distribution width in routine blood tests, but other laboratory indicators are normal, it is not clinically significant at this time, and it is sufficient to strengthen nutrition and develop good lifestyle habits. The main causes of low platelet distribution are as follows: 1. Anemia: Laboratory tests can reveal a decrease in whole blood cells, unequal red blood cell size, low platelet distribution width, etc. Patients can have symptoms such as nail bed, mouth and lips, pale skin mucosa, mental depression, skin petechiae, and bleeding gums. Treatment should actively search for the cause of anemia and remove the causative factors. For patients with iron deficiency anemia can be treated with iron supplements under the guidance of doctors; for nutritional anemia caused by folic acid and vitamin B12 deficiency, supplemental folic acid preparations and oral or intramuscular vitamin B12 should be taken as prescribed by doctors; for patients with autoimmune hemolytic anemia, glucocorticoid therapy, such as methylprednisolone and dexamethasone, can be applied; for patients with aplastic anemia, androgens, such as Testosterone propionate, Danazol and other drugs; 2. Malignant tumors: Patients with malignant tumors who have undergone chemotherapy and radiotherapy may experience bone marrow suppression, i.e., thrombocytopenia and low platelet distribution width. The treatment of malignant tumor is mainly based on surgery, and auxiliary application of radiotherapy, chemotherapy, immunotherapy, targeted therapy, etc.; 3. Bacterial infection: Bacterial infection causes abnormal autoantibodies of platelets, which leads to abnormal platelet function and low platelet distribution width. Treatment can be done with anti-inflammatory drugs, such as cefazoxime, metronidazole, penicillin, and ofloxacin, etc.; 4. Viral infections: Viral infections lead to impaired platelet antibodies, which can cause an increase in anti-viral antibodies in the patient’s serum, resulting in an increase in platelet surface antibodies, which can lead to a low platelet distribution width. This situation should be treated with antiviral drugs under the guidance of a doctor, such as ribavirin, oseltamivir, etc.; 5, reactive thrombocytosis: can be manifested as low platelet distribution width, but need to be combined with the results of red blood cells, hemoglobin, platelets for a comprehensive judgment, otherwise no clinical significance, and no special treatment; 6, other: ionizing radiation, reduced platelet production, etc. can lead to The platelet width is low. The low platelet distribution width caused by ionizing radiation can generally be relieved by itself after moving away from radiation. If it is caused by a decrease in platelet production, the cause should be actively investigated and treated, and if necessary, platelets can be imported for supportive treatment. Anemia is defined as a lower than normal total red blood cell volume in the body’s blood, while the determination of total red blood cell volume is related to hemoglobin concentration, red blood cell count, and hematocrit, and is not directly related to platelet distribution width. Therefore, the low platelet distribution width is not the only indicator to determine whether anemia is present.