H. pylori positivity requires quadruple therapy, i.e. one proton pump inhibitor + one bismuth + two antibiotic drugs. Positive Helicobacter pylori indicates the current presence of Helicobacter pylori infection, this bacterium is associated with gastric cancer, gastric polyps, peptic ulcer, gastritis, etc. Conventional quadruple therapy, i.e., one proton pump inhibitor + one bismuth + two antibiotic medications, the medications are commonly used as omeprazole or rabeprazole, bismuth potassium citrate or bismuth pectin, clarithromycin, amoxicillin and metronidazole. Anti-Helicobacter pylori infection treatment course of 10-14 days, usually 30 days after stopping the drug, go to the hospital to do H. pylori test, if the test results are negative indicating cure, such as positive, the need to stop the drug for 3 months and then continue to eradicate, and at the same time, need to identify the reasons for failure to cure. If there is Helicobacter pylori infection, accompanied by bloating, nausea, acid reflux and other digestive symptoms, it is recommended to consult the gastroenterology department in a timely manner, complete gastroscopy and other tests to assess the digestive tract, active treatment, medication under the guidance of the doctor, pay attention to follow the doctor’s instructions to take medication, quit smoking and alcohol, avoid spicy and stimulating foods, eat a regular diet to avoid self-medication, which will lead to delayed condition.