Gout eating amoxicillin didn’t work, gout is urate deposition leading to joint inflammation, amoxicillin is a penicillin anti-infective drug, mainly used for anti-infective treatment, no analgesic effect. Acute gouty arthritis pain is due to the inflammatory response caused by gout stone deposition, can be relieved by the application of anti-inflammatory drugs to relieve the pain, commonly used drugs include indomethacin, diclofenac and so on. For acute pain within 48 hours of onset, a small dose of colchicine liquid can be effective in relieving pain symptoms. Amoxicillin is indicated for infections such as otitis media, sinusitis, pharyngitis, and tonsillitis in adults and children caused by sensitive bacteria (non-lactamase-producing strains) such as Streptococcus hemolyticus, Streptococcus pneumoniae, Staphylococcus staphylococcus, or Haemophilus influenzae. The most common adverse drug reactions are diarrhea, nausea, and rash. Penicillin allergy and penicillin skin test positive patients are prohibited. Pay attention to ask for allergy history before using the drug, and must do penicillin sodium skin test. It is recommended that gout patients standardize the use of medication as early as possible under the guidance of a physician, and avoid taking medication on their own to avoid serious consequences.