A burst of nerve pain in the thigh, the specific causes are as follows: a. lumbar intervertebral disc herniation compression nerve, can appear intermittent thigh pain, obvious after exertion or weight bearing, the imaging examination of the lumbar spine can be clearly diagnosed, treatment with local physiotherapy, oral nerve nutrition and calcium treatment, if necessary, feasible surgery. The main manifestations of ischemic necrosis of femoral head are intermittent slope walking, leg pain, and aggravation after exertion. The diagnosis can be made by hip radiograph, CT or MRI, and conservative treatment and symptom reduction are the main reasons, but surgery for femoral head replacement is needed if necessary. Third, calcium deficiency also causes paroxysmal pain in the thigh, mostly after exertion or cold. The episodes can be irregular. Blood calcium monitoring can assist in the diagnosis, and oral or intravenous calcium supplementation can be given. Fourth, trauma, strenuous exercise, lower limb venous thrombosis and other diseases can also be caused. Therefore, when the above-mentioned symptoms appear, attention should be paid to further clarify the cause, combine with the patient’s symptoms, signs and auxiliary examinations, and give treatment after clear diagnosis to avoid misdiagnosis and delay of the disease.