Lupus erythematosus can be categorized as “erythroderma” in Chinese medicine, which is characterized by fever and toxin blazing (too much fire in the body), qi stagnation and blood stasis, and yin deficiency and fire exuberance. Rhinoceros Horn Dihuang Tang and Six-flavored Di Huang Pills can be used to treat the symptoms. 1. Heat and toxicity blazing evidence: manifested as facial butterfly-shaped erythema, bright red color, muscle, joint pain, skin purple spots, high fever, convulsions, irritability and thirst, etc.; treatment should be to clear heat and cool the blood, to resolve the spots and detoxification, can be taken rhinoceros horn dihuang soup combined with yellow rhizome and detoxification soup, etc.. Yang deficiency, blood loss, spleen and stomach weakness should not use rhinoceros horn and rhizome soup; Huanglian detoxification soup for a long time or overdose is easy to hurt the spleen and stomach, should not be used by people who are not overflowing with fire. 2. Qi stagnation and blood stasis: manifested as keratinous embolism, skin atrophy, tiredness and fatigue, erythema and dark stagnation, etc.; the treatment should dredge the liver and regulate qi, activate blood circulation and eliminate blood stasis, and can be taken with Blood Palace and Blood Stasis Soup combined with Free and Easy San, etc.. Pregnant women should not use Blood Mansion and Blood Stasis Relieving Soup. The contraindications of Puanxuan are not clear yet. 3. Yin deficiency and exuberant fire syndrome: manifested as dark red rash, persistent low or irregular fever, arthralgia, heel pain, heat in the hands and feet, flushed face and insomnia; the treatment should nourish yin and lower the fire, and can be taken as Liouweidihuang Pill combined with Bone-cleansing Powder. For those with spleen deficiency and diarrhea, be cautious of using Liufei Di Huang Wan. The contraindications of Bone Clearing Powder are not clear. The adverse effects of the above drugs are not clear, and it is recommended that they be used under medical supervision. In addition, this disease is an autoimmune disease with complexity, and is mainly treated with a combination of traditional Chinese and Western medicine in the clinic. If you feel unwell, it is recommended that you consult a doctor in time and follow the doctor’s instructions.