Lung adenocarcinoma with bone metastasis can be treated with chemotherapy, radiotherapy, targeted therapy and bone density enhancement to prolong the survival period and improve the quality of life. 1. Chemotherapy: Lung adenocarcinoma with bone metastasis can be treated with double-drug combination of docetaxel, paclitaxel, pemetrexed and platinum-containing drugs such as carboplatin and cisplatin. Chemotherapeutic drugs can directly kill cancer cells in bone metastasis and all parts of the body. 2. Radiotherapy: Lung adenocarcinoma bone metastasis can be treated by irradiating the metastatic foci with radiation, which can destroy the deoxyribonucleic acid in the nucleus of the cancer cells through the energy released by the radiation particles, and then kill the cancer cells. 3. Targeted therapy: if patients with lung adenocarcinoma with bone metastasis have specific gene mutations through genetic test, they can use targeted drugs against these gene mutations, such as ositinib, buclatinib, gefitinib and so on. 4. Immunotherapy: patients can be tested for PD-1/PD-L1 gene, and if there is relevant gene expression, PD-1/PD-L1 inhibitors can be chosen for immunotherapy. 5. Enhance bone density: cancer cells metastasized to bones can cause invasion and destruction of bone tissues, which may easily lead to pathological fracture. Regular injections of zoledronic acid, desutumumab and other drugs to increase bone density can be used to prevent cancer cells from destroying bones. Bone cement can also be used to reinforce the severely damaged bones. The above medications should be prescribed by the doctor. Patients are advised to actively seek medical treatment and cooperate with the treatment in order to strive for a good prognosis.