Patients depressed with insomnia, generally the most widely used drugs in clinical practice are mirtazapine and agomelatine. This is because this antidepressant improves mood and treats depression on the premise that it can also improve sleep. Most depressed patients are accompanied by insomnia and early awakening, and lack of sleep can in turn affect depressed mood. For the treatment of depression with insomnia, while applying antidepressants such as fluoxetine, paroxetine, sertraline, etc., you can also apply drugs to improve sleep, such as benzodiazepines, including diazepam, lorazepam, etc. The two can be applied in combination to improve depression and improve sleep at the same time, and after sleep is improved, depression will also be relieved to a certain extent. In turn, the depression will improve the sleep situation, and the two will interact with each other.