Upper eyelid crease may be dry weather, hereditary and other physiological factors, may also be related to atopic dermatitis and other diseases, need to take general measures for the cause of the disease, medication and other ways to solve. 1. Physiological factors: upper eyelid crease may be caused by dry weather, should pay attention to skin moisturizing, timely replenishment of water. Maintain good habits, regular work and rest, active sports. Generally there is no need for treatment, if you feel the impact on aesthetics, you can choose to hydrazine injection, photorejuvenation and other methods of medical beauty, able to replenish water, so that the skin is moisturized and smooth. 2. Atopic dermatitis: the upper eyelid crease may be the manifestation of atopic dermatitis, should actively seek and eliminate the triggering factors, can be used under the guidance of the doctor glucocorticosteroid drugs, such as hydrocortisone, dexamethasone cream, etc., to reduce the inflammatory response, promote the healing of the skin lesions, so as to alleviate the symptoms of the disease. There are many reasons that lead to folds in the upper eyelid, and it is recommended that patients go to the hospital, clarify the cause of the disease, and standardize the treatment under the guidance of the doctor.