The common causes of high indirect bilirubin include non-disease factors and disease factors. Non-disease factors include after a full meal, physiological jaundice, etc. Disease factors are mostly found in cirrhosis, viral hepatitis, hemolytic anemia, etc. 1. Non-disease factors: under normal circumstances, indirect bilirubin can be transiently elevated after a full meal, and the value can return to normal in fasting state, so there is no need to consult a doctor. In addition, newborn babies can have physiologic jaundice that causes elevated indirect bilirubin, which usually subsides within 2 weeks and does not require treatment. 2. Disease factors: There are many disease factors leading to high indirect bilirubin, among which cirrhosis, viral hepatitis and hemolytic anemia are the most common. (1) Cirrhosis: the liver of these patients has different degrees of damage, and there are different degrees of obstacles to bilirubin binding, excretion and uptake, resulting in high indirect bilirubin. (2) Viral hepatitis: patients with viral hepatitis have a certain degree of hepatocellular damage, and the excretion, uptake and metabolism of indirect bilirubin are weakened, resulting in high indirect bilirubin. (3) Anemia: A large number of red blood cells in these patients are destroyed, resulting in the formation of a very large amount of indirect bilirubin, which exceeds the limit of liver uptake and binding, and weakens the metabolism of bilirubin by the liver to a certain extent, ultimately leading to a high level of indirect bilirubin. Elevated indirect bilirubin needs to be taken seriously, and after ruling out lung disease, it is necessary to consult a doctor in a timely manner, and under the doctor’s guidance, complete the relevant examinations to clarify the cause of the disease, so as to systematically treat the disease.