When copper cyanide is low, it is considered to be hepatobiliary degeneration, and when it is significantly lower, then it is basically considered to be hepatobiliary degeneration, which may be caused by excessive deposition of copper in the liver, resulting in impaired synthesis of copper cyanide. Of course, there are other diseases such as primary biliary cirrhosis, primary biliary atresia, nephrotic syndrome, hypoproteinemia, neonatal, immature infant, malabsorption syndrome, protein leaky gastrointestinal syndrome, etc.