Worldwide, the incidence and mortality rate of pancreatic cancer has been increasing year by year from 2000 to 2009. Because the pancreas is a substantial organ located in the retroperitoneum, the onset of the disease is insidious. In the early stage, the clinical symptoms are non-specific, such as abdominal distension, back discomfort, indigestion, nausea, weight loss, diarrhea, etc., which are also present in other digestive tract diseases, so it is easy to ignore or treat them as general gastric and biliary diseases. It is not until obvious jaundice and pain appear that one will seek medical attention. If the doctor encountered does not have specialized knowledge or is not alert to this disease, then another period of time will be turned around, so pancreatic cancer is difficult to be detected and diagnosed early with poor prognosis. Paying attention to some clinical signals of pancreatic cancer development and strengthening screening for high-risk groups can improve the early diagnosis rate and increase the surgical resection rate. 1. Pay attention to the non-specific symptoms of digestive tract diseases that appeared recently in middle-aged people. You should not treat the above abdominal discomfort, indigestion and abdominal distension as gastric or biliary diseases and buy medicine at will, or resist for a period of time on your own and go to the doctor only when you cannot tolerate them. Because the initial manifestations of digestive system diseases are the same, it is difficult to make an accurate diagnosis without imaging and some special tests; 2, do not always associate jaundice with hepatitis in the first place when it appears, nowadays jaundice due to hepatitis is much less common than jaundice due to benign obstruction of the biliary tract and jugular abdominal tumors. (7) patients with benign lesions distal to major gastric resection, especially those who are more than 20 years postoperative; (8) high risk factors for pancreatic cancer: long-term smoking, heavy alcohol consumption, long-term exposure to harmful chemicals, etc. (4) Spiral CT-enhanced scan of the upper abdomen, ultrasound endoscopy, CA-199 and glutamyl trans-titaniumase test can help in diagnosis and differential diagnosis.