Elderly gray hair may be due to aging, without treatment, but also may be due to vitiligo and other diseases, need to follow the doctor’s advice to take medication, surgical treatment, as well as general measures to regulate. 1. age: the old man due to age, the body function decreases, the hair bulb in the melanocyte tyrosinase activity progressive loss, so that the hair shaft in the gradual loss of pigment, so the old man will appear white hair. This is a normal phenomenon, do not need treatment. 2. Vitiligo: Vitiligo is mainly due to autoimmune, genetic and other factors leading to melanocyte destruction. The main symptoms of patients have white skin, white hair and so on. Vitiligo can follow the doctor’s instructions to use tacrolimus ointment, pimecrolimus cream and other topical calcium-modulated phosphatase inhibitor drugs, as well as topical vitamin D3 derivatives such as capotriol. In addition, patients may opt for phototherapy or localized hair transplants. Gray hair in the elderly may also be caused by taking antimalarial drugs, phenylketonuria, tuberous sclerosis, pernicious anemia and other diseases. It is recommended that after excluding physiological factors, the elderly need to consult a doctor in time to check the cause of the disease and treat the cause of the disease.