Grade II cervical intraepithelial neoplasia was the previous name for what is now called high-grade cervical squamous intraepithelial lesion, which is not serious with timely treatment. High-grade cervical squamous intraepithelial lesions can be triaged with P16 immunohistochemical staining, and negative P16 staining is treated as low-grade cervical squamous intraepithelial lesions, which have the potential to heal on their own, and can be observed and followed up only. If the lesion continues to develop during the follow-up, or if the lesion continues for two years without a tendency to improve, surgical treatment is given. Laser treatment or cryotherapy is given when colposcopy is adequate, and cervical conization is given when colposcopy is inadequate. High-grade cervical squamous intraepithelial lesion with positive P16 immunohistochemical staining is treated as high-grade cervical squamous intraepithelial lesion, which is pre-cancerous and needs to be treated; if colposcopy is sufficient, cervical conical excision or cervical Lipectomy is given. If colposcopy is not sufficient, give cold knife conization of the cervix and further pathologic examination. Timely treatment of squamous intraepithelial lesions of the cervix can block the development of invasive carcinoma of the cervix. It is recommended to consult a regular hospital in time and give appropriate treatment under the guidance of a professional doctor.