Endometrium 15mm thick usually belongs to the endometrial hyperplasia which causes irregular menstruation and the phenomenon of not having menstruation. Patients with endometrial hyperplasia can be categorized into those without atypical hyperplasia and those with atypical hyperplasia, and can be treated with medication and surgery, as prescribed by the doctor. 1. Without atypical hyperplasia: endometrial simple hyperplasia and complex hyperplasia is basically a benign lesion. If the patient does not have clear symptoms, generally no medication is needed. If there is frequent irregular vaginal bleeding or excessive menstrual flow, long menstrual cycle, etc., then natural progesterone can be used for regular withdrawal treatment. 2. Atypical hyperplasia: for those who have fertility requirements, they need to go to the hospital under the guidance of specialists to apply high-efficiency progesterone to carry out drug treatment; for those who do not have fertility requirements, it is feasible to have a total hysterectomy in order to seek a radical cure. The endometrium is 15mm thick and there may be other reasons for not having menstruation, first of all, we should consult the doctor in time, improve the relevant examination, the doctor will clarify the cause of the disease, and then give targeted treatment.