Only one sperm in the semen may be due to obstruction, hypogonadotropic hypogonadism and other causes of azoospermia, which can be treated by drugs and surgery. 1. Obstruction: If the azoospermia is caused by obstruction of the epididymis, it can be treated by vasovaso-epididymal anastomosis; if the azoospermia is caused by obstruction of the vas deferens, it can be treated by vasovasovasostomy. 2. Hypogonadotropic hypogonadotropic hypogonadism: testosterone replacement therapy is feasible. Testosterone replacement therapy for boys usually starts at the age of 14, and the testosterone preparations available include testosterone undecanoate and testosterone enanthate, etc. All the above medications need to be applied under the guidance of a doctor. Only one spermatozoon in the semen can be timely medical treatment according to the cause of the disease.