Swelling in many places after vaccination may be caused by adverse reactions, but we can’t exclude our own disease factors. Swelling in many places of the body after vaccination is first considered to be caused by adverse reactions to vaccines. Including the new crown vaccine, hepatitis B vaccine, etc., due to the allergy to some of the components of the vaccine, similar manifestations can appear, usually can be relieved by themselves, do not need treatment. However, if the disease continues to worsen, we cannot rule out the possibility that it is caused by the disease itself, including kidney disease, poor venous return, liver disease, cardiogenic edema, etc., which can produce similar manifestations. Therefore, it is necessary to consult a doctor in time, under the guidance of the doctor to carry out targeted examination and treatment, to avoid further aggravation of the disease.