Neonatal cholestasis is called infantile cholestasis, caused by various reasons of hepatocellular or capillary bile duct secretion dysfunction, or bile duct pathology resulting in reduced or lack of bile excretion, its treatment is mainly for the original cause, such as infection caused by the general can be cured, inborn genetic metabolic disease can generally only improve the symptoms.
Infantile cholestasis is mainly caused by intrauterine and perinatal infections, inborn genetic metabolic diseases, and intrahepatic bile ducts developmental abnormalities, etc., which are triggered by environmental, genetic and other factors, either individually or jointly. Generally the infection can be cured by active anti-infection treatment, but because of congenital causes can only improve the symptoms.
1. Anti-infective treatment: such as cytomegalovirus infection applying ganciclovir antiviral treatment; bacterial infection applying antibiotics with high concentration in bile distribution, such as cefoperazone; stopping drugs that cause cholestasis, minimizing or stopping parenteral nutrition.
2. Metabolic intervention: lactose-free diet for galactosemia, low tyrosine and low phenylalanine diet for tyrosinemia, and early intervention for hypothyroidism.
All of the above medications should be taken under the supervision of a doctor. It is recommended that babies with cholestasis consult a doctor in a timely manner.