The clinical symptoms of Niemann’s disease are mainly divided by age, and there are five common symptoms as follows: 1, acute neurological type. It occurs in infants within half a year of age, mainly manifesting as loss of appetite, vomiting, easy to lose weight, mental retardation, motor impairment, accompanied by jaundice, anemia, etc. 2, non-neurological type. The disease usually develops in childhood, with enlarged liver and spleen and normal intelligence. 3. Juvenile type. Most often seen in childhood with onset at the age of 2-6 years, with unstable walking, dystonia, convulsions, and progressive development of dementia.4. Juvenile type. There is marked jaundice and hepatosplenomegaly, as well as epilepsy, and a decrease in enzyme activity in the patient’s body.5. Adult type. The onset of the disease in adulthood, the patient has normal intelligence, hepatosplenomegaly, a tendency to rage, obsessive-compulsive disorder, and normal enzyme activity in the body. In addition, there are complications such as cardiopulmonary and liver cirrhosis.