High alanine aminotransferase, aspartate aminotransferase and one thousand alpha-fetoprotein may indicate liver malignancy, liver metastasis of malignant tumor of reproductive system and so on. 1. Liver malignant tumor: when patients develop liver malignant tumor, such as primary hepatocellular carcinoma, it will lead to liver tissue lesions, liver cells are destroyed, resulting in transaminases into the blood, appearing alanine aminotransferase and aspartate aminotransferase is high; alpha-fetoprotein is an important indicator for detecting liver malignant tumor, alpha-fetoprotein more than 1,000 is much higher than the normal value, which is mostly suggestive of the development of liver malignant tumor. 2. Liver metastasis of reproductive system tumor: alpha-fetoprotein is also an important index for detecting trophoblastic malignant tumor, when patients have reproductive system malignant tumor, it will also lead to elevation of alpha-fetoprotein, and when the tumor cells metastasize to the liver, it will lead to elevation of aminotransferase in the blood. When patients have the above situations, it is recommended that they go to the hospital in time, clarify the cause of the disease under the guidance of professional physicians, and carry out targeted treatment or therapy.