It is recommended that patients go to the hospital to improve the relevant examination and treatment under the guidance of the doctor.
ERBB3 (also known as HER3, Human Epidermal Growth Factor Receptor 3) is a member of the epidermal growth factor receptor family (EGFR).
ERBB3 is expressed in the gastrointestinal tract, reproductive system, skin, nervous system, urinary tract and endocrine system in normal adults . Overexpression of ERBB3 protein has been found to be associated with many cancers, including prostate, bladder, lung, colorectal, gastric, and breast cancers.
Studies have shown that even in the absence of ligands, ERBB3 forms dimers with ERBB2 when it is overexpressed, which activates downstream signals leading to tumorigenesis . Therefore, by targeting ERBB3, blocking the composition of ERBB3/ERBB2 heterodimers or blocking the development of NRG1 intercalation in cells will provide new avenues for cancer therapy.