Surgery is mandatory after birth for fetal pulmonary isolation because there is no other effective treatment in clinical practice, and the best results can only be achieved by means of surgical treatment. Pulmonary Isolation is a rare congenital disease with malformations of lung development, in which the diseased lung tissue exists separately from the normal lung, and can be categorized into Intrapulmonary Pulmonary Isolation and Extrapulmonary Pulmonary Isolation. Patients with pulmonary segregation often have recurrent respiratory tract infections, such as cough, sputum, fever, chest pain, hemoptysis, etc. Infants and young children may have cyanosis, dyspnea, dysphagia, and dysphagia. Drug treatment is only symptomatic, and surgical treatment is needed to cure the disease, either thoracoscopic surgery or surgical open-heart surgery. In conclusion, after the birth of a fetus with pulmonary isolation, surgical treatment is necessary and is the best way to treat the disease.