Adenosylmethionine butadisulfate, clinically known as Simetai, is a drug that promotes hepatic metabolism and detoxification, and its main effects are as follows: 1. It can carry out transmethylation in the liver, enhance hepatocyte membrane fluidity, improve Na+-K+ATPase activity, thus accelerating bile excretion and reducing bile sludge in hepatocytes. 2. It has not only transmethylation, but also transulfuration, promoting sulfide such as synthesis of cysteine and glutathione, which has detoxification effect and protects liver cell membrane damage. It is clinically indicated for intrahepatic cholestasis caused by various reasons, such as liver failure, post-hepatitis cirrhosis, cholestasis due to drug-related liver injury, or liver disease during pregnancy such as intrahepatic cholestasis, acute fatty liver in pregnancy, etc.